over 24 hours every 21 days without growth factor support. The median age of the patients was 32.5 years (range, 18-49 years). The testis was the primary site of Genitourinary Oncology Program, Indiana Unitumor for 13 patients (72%) and the tumor was extragonadal in 5 patients (28%).
Phase II trial of topotecan in patients with cisplatin-refractory germ cell tumors
β Scribed by Heidi Sonya Puc; Dean F. Bajorin; George J. Bosl; Alison Amsterdam; Robert J. Motzer
- Publisher
- Springer US
- Year
- 1995
- Tongue
- English
- Weight
- 171 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0167-6997
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π SIMILAR VOLUMES
With the use of cisplatin-based combination chemotherapy, metastatic testicular germ-cell tumors can be cured in 70% to 80% of patients. The combination of cisplatin, etoposide and bleomycine (PEB) is considered standard therapy.
A prospective study of four cycles of etoposide with ifosfamide and cisplatin (VIP) chemotherapy was conducted in 42 germ cell tumor (GCT) patients who were refractory to cisplatin with etoposide/vinblastine-based therapy. Forty patients were evaluable for response. Ten patients (25%) had a complete