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Phase II Trial of T138067, a Novel Microtubule Inhibitor, in Patients with Metastatic, Refractory Colorectal Carcinoma

✍ Scribed by Jordan D. Berlin; Alan Venook; Emily Bergsland; Mace Rothenberg; A. Craig Lockhart; Lee Rosen


Book ID
119935127
Publisher
CIG Media Group, LP.
Year
2008
Tongue
English
Weight
87 KB
Volume
7
Category
Article
ISSN
1533-0028

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## Abstract ## BACKGROUND The similarity between the mechanism of action between docetaxel and estramustine generated the hypothesis of synergistic antimicrotubule effects and cytotoxicity when the two agents are combined. In addition, it has been demonstrated that estramustine binds P‐glycoprotei