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Phase II trial of 5 day continuous intravenous infusion of 6-thioguanine in patients with recurrent and metastatic squamous cell carcinoma of the head and neck

✍ Scribed by Flavio Kruter; Mario Eisenberger; Victoria Sinibaldi; Christine Engstrom; Maria Jacobs; Jeffrey Abrams; Chandra Belani; William Gray; Steven Krasnow


Publisher
Springer US
Year
1992
Tongue
English
Weight
221 KB
Volume
10
Category
Article
ISSN
0167-6997

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The chemotherapeutic treatment of recurrent and/or metastatic squamous cell carcinoma (SCC) of the head and neck (H & N) has a very dismal prognosis, with survival usually not exceeding 1 year. Reported objective response rates vary between 3% and 70%. This difference appears largely attributable to