Phase II trial of 5 day continuous intravenous infusion of 6-thioguanine in patients with recurrent and metastatic squamous cell carcinoma of the head and neck
β Scribed by Flavio Kruter; Mario Eisenberger; Victoria Sinibaldi; Christine Engstrom; Maria Jacobs; Jeffrey Abrams; Chandra Belani; William Gray; Steven Krasnow
- Publisher
- Springer US
- Year
- 1992
- Tongue
- English
- Weight
- 221 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0167-6997
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## Abstract ## Objective. We assessed the response rate and the toxicity of cisplatin plus vinorelbine in patients with this condition. ## Patients and Method. Fortyβtwo patients were included. Therapy consisted of cisplatin, 100 mg/m^2^ on day 1, and vinorelbine, 25 mg/m^2^ on days 1 and 8, giv
The chemotherapeutic treatment of recurrent and/or metastatic squamous cell carcinoma (SCC) of the head and neck (H & N) has a very dismal prognosis, with survival usually not exceeding 1 year. Reported objective response rates vary between 3% and 70%. This difference appears largely attributable to