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Phase II study of the histone deacetylase inhibitor belinostat (PXD101) for the treatment of myelodysplastic syndrome (MDS)

✍ Scribed by Amanda Cashen; Mark Juckett; Alcee Jumonville; Mark Litzow; P. J. Flynn; John Eckardt; Betsy LaPlant; Kristina Laumann; Charles Erlichman; John DiPersio


Publisher
Springer
Year
2011
Tongue
English
Weight
131 KB
Volume
91
Category
Article
ISSN
0939-5555

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## Abstract Histone deacetylase inhibitors (HDACi) represent a promising new class of anticancer agents. In the current investigation, we examined the activity of the HDACi belinostat in preclinical models of prostate cancer. __In vitro__ proliferation assays demonstrated that belinostat potently i