To determine the efficacy of amonafide in patients with advanced, measurable pancreatic adenocarcinoma, 15 patients previously untreated with chemotherapy were entered on a phase II trial. The starting dose was 400 mg/m 2 administered daily over 1 hr for 5 consecutive days repeated every 3 weeks. Be
Phase II study of gemcitabine in advanced colorectal adenocarcinoma
โ Scribed by Dennis F. Moore; Richard Pazdur; Karen Daugherty; Peter Tarassoff; James L. Abbruzzese
- Publisher
- Springer US
- Year
- 1992
- Tongue
- English
- Weight
- 267 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0167-6997
No coin nor oath required. For personal study only.
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## Abstract ## BACKGROUND Care for patients with advanced sarcomas is mainly palliative. Gemcitabine, a nucleoside antimetabolite, is an analog of deoxycytidine that has shown antitumor activity in several tumors. The aim of the current study was to determine the clinical activity of gemcitabine i
Twenty one evaluable patients with advanced colorectal carcinoma were treated with continuous infusion of spirogermanium at a median daily dose of 150 mg/rn 2 (range 120-210) for five consecutive days every 14 days. Treatments were accomplished by using outpatient infusion devices. Fifteen patients