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Phase II study of CI-958 in colorectal cancer

โœ Scribed by Anthony F. Shields; Philip A. Philip; Patricia M. LoRusso; Ann M. Ferris; Mark M. Zalupski

Book ID
105994439
Publisher
Springer
Year
1999
Tongue
English
Weight
67 KB
Volume
43
Category
Article
ISSN
0344-5704

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BACKGROUND. CI-958 is a synthetic intercalating agent of a new chemical class, the benzopyranoindazoles, with promising preclinical activity. Its mechanism of action is thought to be stabilization of the cleavable complex of DNA with topoisomerase II, as well as DNA helicase blockade. It is thought