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Phase II study of carminomycin in a human tumor cloning assay

โœ Scribed by Marcel Rozencweig; Charlotte Sanders; William Rombaut; Nadine Crespeigne; Genevieve Decoster; Yvon Kenis; Jean Klastersky

Publisher
Springer US
Year
1984
Tongue
English
Weight
305 KB
Volume
2
Category
Article
ISSN
0167-6997

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โœฆ Synopsis

The anticancer activity of carminomycin was investigated in a human tumor cloning assay. No efficacy could be identified in the WiDr and the MCF7 cell lines which were highly responsive to doxorubicin. In addition, drug testing experiments were carried out in samples of various malignancies freshly obtained from 86 patients of whom 54 had not received prior anthracyclines. A reduction in the number of tumor colony forming units by 50~ or more was seen in 1/26 breast cancers, 1/22 ovarian cancers and 1/7 melanomas. Crossresistance studies indicated that eight tumors were responsive to doxorubicin only and one to carminomycin only whereas two were sensitive to both and 73 were resistant to both. This in vitro Phase 1I study corroborates the disappointing clinical results achieved with carminomycin.

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