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Phase II clinical trial of cis dichlorodiammine platinum (Cis DDP) in metastatic brain tumors

✍ Scribed by Krsto Kolarić; Anton Roth; Ivo Jeličic; Anto Matković

Book ID
112295445
Publisher
Springer-Verlag
Year
1982
Tongue
English
Weight
740 KB
Volume
104
Category
Article
ISSN
1432-1335

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Thirty-one loading courses of 5-FU and cis-platinum (11) diaminedichloride (CPD) were given to 27 patients with a variety of malignancies. Up to 16 mg/kg/day of 5-FU and 2.5 mg/kg of the platinum were reached with minimal toxicity. Nausea (27/31) and vomiting (23/31) were the most frequent symptoms,