## Background: Both twice daily fractionated radiotherapy and concurrent cisplatin with once-daily radiotherapy have been shown to improve local disease control in patients with head and neck cancer. the objective of this phase i trial was to determine the maximum tolerated dose of cisplatin which
Phase II Trial of Hyperfractionated Accelerated Split-Course Radiochemotherapy with 5-FU and Cis-DDP in Advanced Head and Neck Cancer
β Scribed by Antje Ernst-Stecken; Gerhard Grabenbauer; Heinrich Iro; Ludwig Plasswilm; Rolf Sauer
- Publisher
- Springer
- Year
- 2004
- Tongue
- German
- Weight
- 331 KB
- Volume
- 180
- Category
- Article
- ISSN
- 0179-7158
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ## Background. Patients with local recurrences or new head and neck primary tumors in previously irradiated tissues have few options for salvage treatment. One option for select patients is to undergo reirradiation with concurrent chemotherapy. The purpose of this study is to report th
## Abstract ## Background Almost all concurrent chemoradiation regimens for head and neck are platinum based; however, cisplatin is associated with severe renal, otoβ, and neurotoxicity. Hydroxyurea (HU) has been associated with fewer irreversible toxicities. We obtained HU in parenteral form to b