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Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma

✍ Scribed by Butowski, N.; Chang, S. M.; Lamborn, K. R.; Polley, M.-Y.; Pieper, R.; Costello, J. F.; Vandenberg, S.; Parvataneni, R.; Nicole, A.; Sneed, P. K.

Book ID: 111858100
Publisher: Duke University Press
Year: 2011
Tongue: English
Weight: 173 KB
Volume: 13
Category: Article
ISSN: 1522-8517
DOI: 10.1093/neuonc/nor130

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## Abstract ## BACKGROUND Currently, the survival of patients age > 70 years with glioblastoma multiforme (GBM) ranges from 4 months to 6 months, although radiotherapy and/or chemotherapy may prolong survival in certain subgroups. Temozolomide is an oral chemotherapeutic agent with efficacy agains