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Phase I trial of the matrix metalloproteinase inhibitor BAY12-9566 in patients with advanced solid tumors

✍ Scribed by Elisabeth I. Heath; Seamus O'Reilly; Rachel Humphrey; Pavur Sundaresan; Ross C. Donehower; Susan Sartorius; John M. Kennedy; Deborah K. Armstrong; Michael A. Carducci; Mel J. Sorensen; Karen Kumor; Sean Kennedy; Louise B. Grochow

Publisher
Springer
Year
2001
Tongue
English
Weight
90 KB
Volume
48
Category
Article
ISSN
0344-5704

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## Abstract ## BACKGROUND. Bortezomib is the first proteasome inhibitor to show preliminary evidence of activity against solid tumors. Findings from preclinical studies prompted a Phase I trial to determine the maximum tolerated dose (MTD) and dose‐limiting toxicities (DLTs) of bortezomib in combi