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Phase I trial of continuous infusion 5-aza-2′-deoxycytidine

✍ Scribed by A. Aparicio; C. A. Eads; L. A. Leong; P. W. Laird; E. M. Newman; T. W. Synold; S. D. Baker; M. Zhao; J. S. Weber

Book ID
105991740
Publisher
Springer
Year
2003
Tongue
English
Weight
307 KB
Volume
51
Category
Article
ISSN
0344-5704

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Phase I study on 5-aza-2′-deoxycytidine
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Ahstract--A Phase I study with 5-aza-2'-deoxycytidine (5-AZA-CdR) was performed on children with acute leukemia who were resistant to conventional chemotherapy. The objective of this study was to find the dose-schedule of 5-AZA-CdR that produced a potent antileukemic effect and to evaluate its toxic