Phase I-trial of a methotrexate — Albumin conjugate (MTX-HSA) in cancer patients
✍ Scribed by Hartung, G.; Stehle, G.; Sinn, H.; Schrenk, H.H.; Heeger, S.; Kränzle, M.; Fiebig, H.H.; Maier-Borst, W.; Heene, D.L.; Queißer, W.
- Book ID
- 123260470
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 393 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0959-8049
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📜 SIMILAR VOLUMES
Methotrexate covalently bound to human serum albumin in a 1:1 molar ratio (MTX-HSA) is a new macromolecular drug which is currently being studied in phase I clinical trials by the German Association for Medical Oncology (AIO) Phase I/II study group. Previous studies have shown that MTX-HSA differs f
The monoclonal antibody (MAb) 791T/36 which has previously been shown to localise in colorectal cancer has been conjugated to methotrexate (MTX) for potential use as a chemotherapeutic agent in malignant disease. To examine its biodistribution and tumour localisation, 16 patients with primary colore