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Phase I study of the antifolate N10-propargyl-5,8-dideazafolic acid, CB 3717

✍ Scribed by Sessa, C.; Zucchetti, M.; Ginier, M.; Willems, Y.; D'Incalci, M.; Cavalli, F.

Book ID: 122711091
Publisher: Elsevier Science
Year: 1988
Weight: 674 KB
Volume: 24
Category: Article
ISSN: 0277-5379
DOI: 10.1016/0277-5379(88)90313-6

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Serum aspartate transaminase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (yGT) activities and the serum ALP isoenzyme pattern have been measured in eleven patients undergoing treatment with CB3717. There were increases in the activity of all three enzymes. The ALP isoenzyme pat