✦ LIBER ✦
Intestinal alkaline phosphatase isoenzyme in patients with primary liver cancer during treatment with N10 propargyl 5, 8-dideazafolic acid (CB 3717)
✍ Scribed by Dr. P. K. Buamah; A. W. Skillen; A. J. Cassells-Smith; O. F. W. James; A. L. Harris
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 337 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0022-4790
No coin nor oath required. For personal study only.
✦ Synopsis
Serum aspartate transaminase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (yGT) activities and the serum ALP isoenzyme pattern have been measured in eleven patients undergoing treatment with CB3717. There were increases in the activity of all three enzymes. The ALP isoenzyme pattern showed an increased contribution of the intestinal isoenzyme to the serum ALP activity. This may be due to increased intestinal mucosal leakage or impaired uptake and breakdown of the intestinal isoenzyme by the liver.