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Phase I Study of Eniluracil, Oral 5-Fluororacil and Gemcitabine in Patients with Advanced Malignancy

✍ Scribed by Sherry Morgan-Meadows; James P. Thomas; Daniel Mulkerin; Jordan D. Berlin; Howard Bailey; Kim Binger; Jennifer Volkman; Dona Alberti; Chris Feierabend; Rebecca Marrocha; Rhoda Z. Arzoomanian; George Wilding


Book ID
110398227
Publisher
Springer US
Year
2002
Tongue
English
Weight
63 KB
Volume
20
Category
Article
ISSN
0167-6997

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## Abstract ## BACKGROUND Pegylated liposomal doxorubicin (PEG‐LD) and gemcitabine have single‐agent activity in breast and ovarian carcinoma patients. We conducted a Phase I trial to evaluate the maximum tolerated dose (MTD) and toxicities of this combination in patients with advanced malignancie

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## Abstract ## PURPOSE The authors conducted a single‐institution Phase I clinical trial to determine the maximum tolerated doses and to define the toxic effects of oral eniluracil and oral 5‐fluorouracil (5‐FU) combined with docetaxel in patients with metastatic breast carcinoma. ## PATIENTS AND