Phase I Study of Eniluracil, Oral 5-Fluororacil and Gemcitabine in Patients with Advanced Malignancy
β Scribed by Sherry Morgan-Meadows; James P. Thomas; Daniel Mulkerin; Jordan D. Berlin; Howard Bailey; Kim Binger; Jennifer Volkman; Dona Alberti; Chris Feierabend; Rebecca Marrocha; Rhoda Z. Arzoomanian; George Wilding
- Book ID
- 110398227
- Publisher
- Springer US
- Year
- 2002
- Tongue
- English
- Weight
- 63 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0167-6997
No coin nor oath required. For personal study only.
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## Abstract ## BACKGROUND Pegylated liposomal doxorubicin (PEGβLD) and gemcitabine have singleβagent activity in breast and ovarian carcinoma patients. We conducted a Phase I trial to evaluate the maximum tolerated dose (MTD) and toxicities of this combination in patients with advanced malignancie
## Abstract ## PURPOSE The authors conducted a singleβinstitution Phase I clinical trial to determine the maximum tolerated doses and to define the toxic effects of oral eniluracil and oral 5βfluorouracil (5βFU) combined with docetaxel in patients with metastatic breast carcinoma. ## PATIENTS AND