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Phase I oncology trials: risks and benefits vary by trial type

Book ID
120854698
Publisher
Adis International Limited (now part of Wolters Kluwer Health)
Year
2005
Weight
120 KB
Volume
&NA;
Category
Article
ISSN
1173-8324

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Risks and benefits associated with novel
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✍ Shlomo A. Koyfman; Manish Agrawal; Elizabeth Garrett-Mayer; Benjamin Krohmal; El πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 210 KB

## Abstract ## BACKGROUND. Although aggressive dose escalation strategies were designed to improve the risk‐benefit profile of phase 1 oncology trials, they have not been adequately studied. The prevalence of several novel trial designs and their association with a variety of clinical endpoints wa