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Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer

✍ Scribed by Eardie A. Curry; Daryl J. Murry; Christy Yoder; Karen Fife; Victoria Armstrong; Harikrishna Nakshatri; Michael O’Connell; Christopher J. Sweeney

Book ID
111579910
Publisher
Springer US
Year
2004
Tongue
English
Weight
167 KB
Volume
22
Category
Article
ISSN
0167-6997

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✍ James Babb; André Rogatko; Shelemyahu Zacks 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 172 KB 👁 1 views

We describe an adaptive dose escalation scheme for use in cancer phase I clinical trials. The method is fully adaptive, makes use of all the information available at the time of each dose assignment, and directly addresses the ethical need to control the probability of overdosing. It is designed to