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Phase-I dose escalation and sequencing study of docetaxel and continuous infusion topotecan in patients with advanced malignancies

✍ Scribed by James A. Posey; Hui Wang; JoElle Hamilton; Alma Delgrosso; Ruiwen Zhang; Timothy Freda; William C. Zamboni

Publisher
Springer
Year
2005
Tongue
English
Weight
251 KB
Volume
56
Category
Article
ISSN
0344-5704

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## Abstract ## BACKGROUND Pegylated liposomal doxorubicin (PEG‐LD) and docetaxel have single‐agent activity in several malignancies. The authors conducted a Phase I trial to evaluate the maximum tolerated dose (MTD), toxicities, and effect of dose sequencing of this combination in patients with ad