Phase I clinical trial and pharmacokinetic evaluation of doxorubicin carried by polyisohexylcyanoacrylate nanoparticles
✍ Scribed by Joseph Kattan; Jean-Pierre Droz; Patrick Couvreur; Jean-Pierre Marino; Arnaud Boutan-Laroze; Philippe Rougier; Philippe Brault; Henri Vranckx; Jean-Marc Grognet; Xavier Morge; Hélène Sancho-Garnier
- Publisher
- Springer US
- Year
- 1992
- Tongue
- English
- Weight
- 619 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0167-6997
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Phase I clinical trials are designed to identify an appropriate dose for experimentation in phase II and III studies. I present the results from a simulation study to evaluate the performance of nine phase I designs involving the standard design, the two-stage modified Storer's design, the two-stage
ICRF-187 was given to 62 evaluable patients with advanced solid tumors in a Phase I clinical trial. Weekly infusions were given in dosages ranging from 0.85 g/m2 to 7.42 g/m2 for a total of four weeks with a two week rest period between courses. Dose-limiting hematological toxicity was seen in heavi