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Clinical phase I and pharmacokinetic trial of the new titanium complex budotitane

โœ Scribed by T. Schilling; K. B. Keppler; M. E. Heim; G. Niebch; H. Dietzfelbinger; J. Rastetter; A. -R. Hanauske

Publisher
Springer US
Year
1995
Tongue
English
Weight
466 KB
Volume
13
Category
Article
ISSN
0167-6997

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Phase I clinical trial and pharmacokinet
Phase I clinical trial and pharmacokinetics of weekly ICRF-187 (NSC 169780) infusion in patients with solid tumors
โœ Charles L. Vogel; Elizabeth Gorowski; Enrique Davila; Mario Eisenberger; James K ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Springer US ๐ŸŒ English โš– 823 KB

ICRF-187 was given to 62 evaluable patients with advanced solid tumors in a Phase I clinical trial. Weekly infusions were given in dosages ranging from 0.85 g/m2 to 7.42 g/m2 for a total of four weeks with a two week rest period between courses. Dose-limiting hematological toxicity was seen in heavi