Phase I clinical and pharmacokinetic study of the glucose-conjugated cytotoxic agentd-19575 (glufosfamide) in patients with solid tumors
β Scribed by Toshio Shimizu; Isamu Okamoto; Kenji Tamura; Taroh Satoh; Masaki Miyazaki; Yusaku Akashi; Tomohiro Ozaki; Masahiro Fukuoka; Kazuhiko Nakagawa
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 456 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0344-5704
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π SIMILAR VOLUMES
ICRF-187 was given to 62 evaluable patients with advanced solid tumors in a Phase I clinical trial. Weekly infusions were given in dosages ranging from 0.85 g/m2 to 7.42 g/m2 for a total of four weeks with a two week rest period between courses. Dose-limiting hematological toxicity was seen in heavi
## BACKGROUND. Compared with free drug, sterically stabilized liposomal drug has prolonged circulation time and, thereby, higher tumor selectivity and antitumor activity. The stability in plasma is an important consideration in the formulation of clinically useful liposomal drug. A Phase I study o