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Phase I clinical and pharmacokinetic study of ombrabulin (AVE8062) combined with cisplatin/docetaxel or carboplatin/paclitaxel in patients with advanced solid tumors

✍ Scribed by Bahleda, Rastislav; Sessa, Cristiana; Del Conte, Gianluca; Gianni, Luca; Capri, Giuseppe; Varga, Andrea; Oprea, Corina; Daglish, Byzance; Hospitel, Marie; Soria, Jean-Charles

Book ID
125358959
Publisher
Springer US
Year
2014
Tongue
English
Weight
846 KB
Volume
32
Category
Article
ISSN
0167-6997

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✍ Jacob Lokich πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 70 KB πŸ‘ 2 views

A Phase I and feasibility study of combined docetaxel (D) plus paclitaxel (P) was undertaken to determine the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) for each analogue delivered concomitantly on a weekly schedule. ## METHODS. Patients were accrued in 3-6 patient cohorts to P