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Phase I and Clinical Pharmacology Study of Bevacizumab, Sorafenib, and Low-Dose Cyclophosphamide in Children and Young Adults with Refractory/Recurrent Solid Tumors

✍ Scribed by Navid, F.; Baker, S. D.; McCarville, M. B.; Stewart, C. F.; Billups, C. A.; Wu, J.; Davidoff, A. M.; Spunt, S. L.; Furman, W. L.; McGregor, L. M.; Hu, S.; Panetta, J. C.; Turner, D.; Fofana, D.; Reddick, W. E.; Leung, W.; Santana, V. M.


Book ID
121686066
Publisher
American Association for Cancer Research
Year
2012
Tongue
English
Weight
477 KB
Volume
19
Category
Article
ISSN
1078-0432

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Phase I study of CI-958 in children and
✍ Carola A. S. Arndt; Mark D. Krailo; Wen Liu-Mares; Peter M. Anderson; Gregory H. πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 63 KB πŸ‘ 2 views

BACKGROUND. CI-958 is a synthetic intercalating agent of a new chemical class, the benzopyranoindazoles, with promising preclinical activity. Its mechanism of action is thought to be stabilization of the cleavable complex of DNA with topoisomerase II, as well as DNA helicase blockade. It is thought