Phase I study of CI-958 in children and
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Carola A. S. Arndt; Mark D. Krailo; Wen Liu-Mares; Peter M. Anderson; Gregory H.
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Article
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2001
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John Wiley and Sons
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English
β 63 KB
π 2 views
BACKGROUND. CI-958 is a synthetic intercalating agent of a new chemical class, the benzopyranoindazoles, with promising preclinical activity. Its mechanism of action is thought to be stabilization of the cleavable complex of DNA with topoisomerase II, as well as DNA helicase blockade. It is thought