Phase diagrams of pseudo-binary phospholipid systems II. Selected calorimetric studies on the influence of branching on the mixing properties of phosphatidylcholines

✍ Scribed by Hans-Dieter Dörfler; Peter Miethe

• Publisher: Elsevier Science
• Year: 1990
• Tongue: English
• Weight: 377 KB
• Volume: 54
• Category: Article
• ISSN: 0009-3084
• DOI: 10.1016/0009-3084(90)90060-5

✦ Synopsis

The miscibility properties of branched phosphatidylcholines in mixtures of aqueous dispersions were studied by means of differential scanning calorimetry. The phase diagrams of four pseudo-binary systems from mixing type unbranched phosphatidylcholine/branched phosphatidylcholine/water (50 wt. 070 water) were investigated and discussed. The unbranched dipalmitoylphosphatidylcholine acts as a reference component of the mixtures. The phase diagrams of these four pseudo-binary phosphatidylcholine systems showed some connections between chain structure of the branched phosphatidylcholines and miscibility of the components. A change of the phase diagram type has been observed according to the branching and/or chain length differences of the phosphatidylcholines: complete miscibility and peritectic mixing behaviour. Generally we observed complete miscibility in the high-temperature phase (La-phase) and demixing in the low-temperature phases (gel phase). This is dependent on the branching and chain length differences of the mixing components.