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Phase behavior of mixtures of cholesterol and saturated phosphatidylglycerols

✍ Scribed by N. Borochov; E.J. Wachtel; D. Bach

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
550 KB
Volume
76
Category
Article
ISSN
0009-3084

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✦ Synopsis

The interaction of cholesterol with a series of saturated phosphatidylglycerols was investigated using differential scanning calorimetry and X-ray diffraction. We find that the miscibility of cholesterol in phosphatidylglycerol bilayers is lower than in the corresponding phosphatidylcholine bilayers and decreases with increasing acyl chain length of the phospholipid. The influence of the negative charge of the phosphatidylglycerol on cholesterol miscibility is discussed.

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