## Abstract ## Background The MUC1 protein is a highly glycosylated mucin normally found at the apical surface of mucinβsecreting epithelial cells in many types of tissues. MUC1 is expressed, but heavily underglycosylated, in different human tumors. TG4010 is a viral suspension of a recombinant va
β¦ LIBER β¦
Phase 1 trial of active specific intralymphatic immunotherapy in patients with advanced cancer
β Scribed by Guy Juillard; Pamela Boyer; Charles Yamashiro
- Publisher
- Elsevier Science
- Year
- 1977
- Tongue
- English
- Weight
- 99 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0360-3016
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## Abstract ## BACKGROUND. Preclinical studies have demonstrated that the inhibition of the PI3K/Akt/mTOR pathway restores gefitinib sensitivity in resistant cancer cell lines. A phase 1 study was conducted of the combination of everolimus, an mTOR inhibitor, and gefitinib to determine a daily dos