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Phase 1 and pharmacokinetic study of weekly docosahexaenoic acid-paclitaxel, Taxoprexin®, in resistant solid tumor malignancies

✍ Scribed by Paula M. Fracasso; Joel Picus; Jonathan D. Wildi; Sherry A. Goodner; Allison N. Creekmore; Feng Gao; Ramaswamy Govindan; Matthew J. Ellis; Benjamin R. Tan; Gerald P. Linette; ChauHwei J. Fu; Helen S. Pentikis; Stephen C. Zumbrun; Merrill J. Egorin; Robert E. Bellet


Publisher
Springer
Year
2008
Tongue
English
Weight
396 KB
Volume
63
Category
Article
ISSN
0344-5704

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✍ Paula M. Fracasso; Kerry J. Williams; Ronald C. Chen; Joel Picus; Cynthia X. Ma; 📂 Article 📅 2010 🏛 Springer 🌐 English ⚖ 451 KB

## Purpose UCN-01 (7-hydroxystaurosporine) is a multi-targeted protein kinase inhibitor that exhibits synergistic activity with DNA-damaging agents in preclinical studies. We conducted a Phase I study to determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), pharmacokinetic, and