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A phase I escalating single-dose and weekly fixed-dose study of cetuximab pharmacokinetics in Japanese patients with solid tumors

✍ Scribed by Kuniaki Shirao; Takayuki Yoshino; Narikazu Boku; Ken Kato; Tetsuya Hamaguchi; Hisateru Yasui; Nobuyuki Yamamoto; Yusuke Tanigawara; Arno Nolting; Shinichiro Yoshino

Publisher
Springer
Year
2009
Tongue
English
Weight
342 KB
Volume
64
Category
Article
ISSN
0344-5704

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## Abstract ## BACKGROUND Based on preclinical findings and on the clinical antitumor efficacy of sequential paclitaxel/topotecan and topotecan/etoposide, the authors sought to define the maximum tolerated doses (MTDs) and dose‐limiting toxicities (DLTs) associated with a sequential combination of