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Pharmacotherapy of diseases mediated by 5-lipoxygenase pathway eicosanoids

✍ Scribed by Paul Rubin; Karl W. Mollison

Book ID
113865044
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
220 KB
Volume
83
Category
Article
ISSN
0090-6980

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The purpose of the present study was to determine the effect of the n-6 fatty acid, dihomogammalinolenic acid (DGLA, 20 : 3, n-6) on arachidonic acid (AA) (C20:4) metabolism by human peripheral mononuclear leukocytes (HPML). After incubation of HPML with A23187 (5 ~tM) and DGLA, the cyclooxygenase (