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Inhibition of human leukocyte 5-lipoxygenase by 15-HPETE and related eicosanoids

✍ Scribed by John R. Cashman; Charles Lambert; Elliott Sigal


Book ID
117058489
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
453 KB
Volume
155
Category
Article
ISSN
0006-291X

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The purpose of the present study was to determine the effect of the n-6 fatty acid, dihomogammalinolenic acid (DGLA, 20 : 3, n-6) on arachidonic acid (AA) (C20:4) metabolism by human peripheral mononuclear leukocytes (HPML). After incubation of HPML with A23187 (5 ~tM) and DGLA, the cyclooxygenase (