Pharmacophore Modelling and Virtual Screening for Identification of New Aurora-A Kinase Inhibitors
β Scribed by Xiao-Qiang Deng; Hui-Yuan Wang; Ying-Lan Zhao; Ming-Li Xiang; Pei-Du Jiang; Zhi-Xing Cao; Yu-Zhu Zheng; Shi-Dong Luo; Luo-Ting Yu; Yu-Quan Wei; Sheng-Yong Yang
- Book ID
- 111368549
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 410 KB
- Volume
- 71
- Category
- Article
- ISSN
- 1747-0277
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The stem cell factor receptor (cβKit) has been known to play critical roles in regulating numerous aspects of cellular behavior including cell growth, differentiation, migration and metabolism. In this investigation, a threeβdimensional pharmacophore model of cβKit inhibitors has been e
## Abstract A threeβdimensional pharmacophore model was developed from a series of inhibitors of Aurora A kinase to discover new potent antiβcancer agents using the HypoGen module in the Catalyst software. The pharmacophore model was developed based on the structure of 20 currently available inhibi