Title Page
Disclaimer
Table of Contents
About the Authors
Copyright
Contributors to Teaching/Learning Resources
Reviewers
Preface
Organization
New to This Edition
Additional Teaching/Learning Features
Supplemental Resources
Acknowledgments
We Welcome Your Feedback
To the Student
Learning Strategies
Nursing Process
Vocabulary
Text Notation
Enhanced Typeface
Study Time
Learning Styles
Use of Applications
Flash Cards
Study Groups
Chat Rooms and Discussion Groups
Time Management
Practice Questions
Application of Pharmacology and Making Connections
Studying for Tests
Test-Taking Strategies
Performance Evaluation
Future Application
Part 1 Pharmacology Basics
1 The Nursing Process and Drug Therapy
Overview of the Nursing Process
Assessment
Identification of Human Need Statements
Planning: Outcome Identification
Implementation
Evaluation
Key Points
Critical Thinking Exercises
Review Questions
References
2 Pharmacologic Principles
Overview
Pharmaceutics
Pharmacokinetics
Pharmacodynamics
Pharmacotherapeutics
Pharmacognosy
Pharmacoeconomics
Toxicology
Summary
Key Points
Critical Thinking Exercises
Review Questions
References
3 Lifespan Considerations
Overview
Drug Therapy During Pregnancy
Drug Therapy During Breastfeeding
Considerations for Neonatal and Pediatric Patients
Considerations for Older Adult Patients
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
4 Cultural, Legal, and Ethical Considerations
Cultural Considerations
Legal Considerations
Ethical Considerations as Related to Drug Therapy and Nursing Practice
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
5 Medication Errors
Medication Errors
Issues Contributing to Errors
Preventing, Responding to, Reporting, and Documenting Medication Errors: a Nursing Perspective
Errors Related to the Transition of Care
Summary
Key Points
Critical Thinking Exercises
Review Questions
References
6 Patient Education and Drug Therapy
Overview
Assessment of Learning Needs Related to Drug Therapy
Human Need Statements Related to Learning Needs and Drug Therapy
Planning: Outcome Identification as Related to Learning Needs and Drug Therapy
Implementation Related to Patient Education and Drug Therapy
Evaluation of Patient Learning Related to Drug Therapy
Summary
Key Points
Critical Thinking Exercises
Review Questions
References
7 Over-the-Counter Drugs and Herbal and Dietary Supplements
Over-the-Counter Drugs
Herbals and Dietary Supplements
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
8 Gene Therapy and Pharmacogenomics
Overview
Basic Principles of Genetic Inheritance
Discovery, Structure, and Function of DNA
Gene Therapy
Pharmacogenetics and Pharmacogenomics
Application of the Nursing Process as Related to Genetic Principles
Summary
Key Points
Critical Thinking Exercises
Review Questions
References
9 Photo Atlas of Drug Administration
Preparing for Drug Administration
Enteral Drugs
Parenteral Drugs
Topical Drugs
References
Part 2 Drugs Affecting the Central Nervous System
10 Analgesic Drugs
Overview
Treatment of Pain in Special Situations
Pharmacology Overview
Opioid Drugs
Drug Profiles
Nonopioid and Miscellaneous Analgesics
Drug Profiles
Nursing Process
Assessment
Key Points
Critical Thinking Exercises
Review Questions
References
11 General and Local Anesthetics
Overview
General Anesthetics
Drug Profiles
Drugs for Moderate Sedation
Local Anesthetics
Drug Profiles
Neuromuscular Blocking Drugs
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
12 Central Nervous System Depressants and Muscle Relaxants
Overview
Physiology of Sleep
Benzodiazepines and Miscellaneous Hypnotic Drugs
Drug Profiles
Barbiturates
Drug Profiles
Over-the-Counter Hypnotics
Muscle Relaxants
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
13 Central Nervous System Stimulants and Related Drugs
Overview
Attention-Deficit/Hyperactivity Disorder
Narcolepsy
Obesity
Migraine
Analeptic-Responsive Respiratory Depression Syndromes
Drugs for Attention-Deficit/Hyperactivity Disorder and Narcolepsy
Drug Profiles
Anorexiants
Drug Profiles
Antimigraine Drugs
Drug Profiles
Drugs for Specific Respiratory Depression Syndromes: Analeptics
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
14 Antiepileptic Drugs
Epilepsy
Antiepileptic Drugs
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
15 Antiparkinson Drugs
Indirect-Acting Dopaminergic Drugs
Direct-Acting Dopamine Receptor Agonists
Critical Thinking Exercises
Review Questions
References
16 Psychotherapeutic Drugs
Anxiety Disorders
Affective Disorders
Psychotic Disorders
Critical Thinking Exercises
Review Questions
References
17 Substance Use Disorder
Overview
Opioids
Stimulants
Depressants
Alcohol
Nicotine
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
Part 3 Drugs Affecting the Autonomic Nervous System
18 Adrenergic Drugs
Overview
Sympathetic Nervous System
Adrenergic Drugs
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
19 Adrenergic-Blocking Drugs
Overview
Alpha Blockers
Drug Profiles
Beta Blockers
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
20 Cholinergic Drugs
Overview
Parasympathetic Nervous System
Cholinergic Drugs
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
21 Cholinergic-Blocking Drugs
Parasympathetic Nervous System
Cholinergic-Blocking Drugs
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
Part 4 Drugs Affecting the Cardiovascular and Renal Systems
22 Antihypertensive Drugs
Anatomy, Physiology, and Pathophysiology Overview
Pharmacology Overview
Review of Autonomic Neurotransmission
Adrenergic Drugs
Drug Profiles
Angiotensin-Converting Enzyme Inhibitors
Drug Profiles
Angiotensin II Receptor Blockers
Drug Profile
Calcium Channel Blockers
Diuretics
Vasodilators
Drug Profiles
Miscellaneous Antihypertensive Drugs
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
23 Antianginal Drugs
Overview
Pharmacology Overview
Nitrates and Nitrites
Drug Profiles
Beta Blockers
Drug Profiles
Calcium Channel Blockers
Drug Profiles
Drug Profile
Summary of Antianginal Pharmacology
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
24 Heart Failure Drugs
Overview
Pharmacology Overview
Angiotensin-Converting Enzyme Inhibitors
Drug Profile
Angiotensin II Receptor Blockers
Drug Profile
Angiotensin Receptor-Neprilysin Inhibitors
Drug Profile
Beta Blockers
Aldosterone Antagonists
Drug Profiles
Phosphodiesterase Inhibitors
Drug Profile
Cardiac Glycosides
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
25 Antidysrhythmic Drugs
Dysrhythmias and Normal Cardiac Electrophysiology
Antidysrhythmic Drugs
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
26 Coagulation Modifier Drugs
Overview
Pharmacology Overview
Anticoagulants
Drug Profiles
Antiplatelet Drugs
Drug Profiles
Thrombolytic Drugs
Drug Profile
Antifibrinolytic Drugs
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
27 Antilipemic Drugs
Overview
Lipids and Lipid Abnormalities
Atherosclerotic Plaque Formation
Cholesterol and Coronary Heart Disease
Hyperlipidemias and Treatment Guidelines
Hydroxymethylglutaryl–Coenzyme a Reductase (HMG-CoA Reductase) Inhibitors
Drug Profiles
Bile Acid Sequestrants
Drug Profile
Niacin
Drug Profile
Fibric Acid Derivatives
Drug Profiles
Miscellaneous Antilipemic Drugs
Psck-9 Inhibitors
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
28 Diuretic Drugs
Overview
Pharmacology Overview
Carbonic Anhydrase Inhibitors
Drug Profile
Loop Diuretics
Summary of Major Drug Effects of Loop Diuretics
Drug Profile
Osmotic Diuretics
Drug Profile
Potassium-Sparing Diuretics
Drug Profiles
Thiazides and Thiazide-Like Diuretics
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
29 Fluids and Electrolytes
Overview
Crystalloids
Drug Profile
Colloids
Drug Profiles
Blood Products
Drug Profiles
Physiology of Electrolyte Balance
Potassium
Drug Profiles
Sodium
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
Part 5 Drugs Affecting the Endocrine and Reproductive Systems
30 Pituitary Drugs
Endocrine System
Pituitary Drugs
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
31 Thyroid and Antithyroid Drugs
Thyroid Function
Pathophysiology of Hypothyroidism
Pathophysiology of Hyperthyroidism
Thyroid Replacement Drugs
Drug Profile
Antithyroid Drugs
Drug Profile
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
32 Diabetes Drugs
Insulins
Oral Diabetes Drugs
Injectable Diabetes Drugs
Sodium Glucose Cotransporter Inhibitors (SGLT2 Inhibitors)
Glucose-Elevating Drugs
Critical Thinking Exercises
Review Questions
References
33 Adrenal Drugs
Adrenal System
Adrenal Drugs
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
34 Women's Health Drugs
Female Sex Hormones
Drug Profile
Drug Profiles
Contraceptive Drugs
Drug Profile
Drugs for Osteoporosis
Drug Profiles
Drugs Related to Pregnancy, Labor, Delivery, and the Postpartum Period
Drug Profile
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
35 Men's Health Drugs
Male Reproductive System
Androgens and Other Drugs Pertaining to Men's Health
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
Part 6 Drugs Affecting the Respiratory System
36 Antihistamines, Decongestants, Antitussives, and Expectorants
Overview
Antihistamines
Drug Profiles
Decongestants
Drug Profile
Antitussives
Drug Profiles
Expectorants
Drug Profile
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
37 Respiratory Drugs
Bronchodilators
Nonbronchodilating Respiratory Drugs
Review Questions
References
Part 7 Antiinfective and Antiinflammatory Drugs
38 Antibiotics Part 1
Antibiotics
Beta-Lactam Antibiotics
Macrolides
Tetracyclines
Critical Thinking Exercises
Review Questions
References
39 Antibiotics Part 2
Overview
Pathophysiology of Resistant Infections
Aminoglycosides
Drug Profiles
Quinolones
Drug Profiles
Miscellaneous Antibiotics
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
40 Antiviral Drugs
General Principles of Virology
Overview of Viral Illnesses and Their Treatment
Herpes Simplex Virus and Varicella-Zoster Virus Infections
Hepatitis
Antivirals (Non–Human Immunodeficiency Virus)
Drug Profiles
HIV Infection and AIDS
Drugs Used to Treat Human Immunodeficiency Virus Infection
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
41 Antitubercular Drugs
Pathophysiology of Tuberculosis
Antitubercular Drugs
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
42 Antifungal Drugs
Fungal Infections
Antifungal Drugs
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
43 Antimalarial, Antiprotozoal, and Anthelmintic Drugs
Overview
Pathophysiology of Malaria
Antimalarial Drugs
Drug Profiles
Other Protozoal Infections
Antiprotozoal Drugs
Drug Profiles
Helminthic Infections
Anthelmintic Drugs
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
44 Antiinflammatory and Antigout Drugs
Overview
Nonsteroidal Antiinflammatory Drugs
Drug Profiles
Antigout Drugs
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
Part 8 Chemotherapeutic Drugs and Biologic and Immune Modifiers
45 Antineoplastic Drugs Part 1
Overview
Targeted Drug Therapy
Cell Cycle–Specific Antineoplastic Drugs
Drug Profiles
Drug Profiles
Drug Profiles
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
46 Antineoplastic Drugs Part 2
Overview
Cell Cycle–Nonspecific Antineoplastic Drugs
Drug Profiles
Drug Profiles
Miscellaneous Antineoplastics
Drug Profiles
Hormonal Antineoplastics
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
47 Biologic Response–Modifying and Antirheumatic Drugs
Overview of Immunomodulators
Pharmacology Overview
Drug Profiles
Drug Profiles
Drug Profiles
Drug Profiles
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
48 Immunosuppressant Drugs
Immune System
Immunosuppressant Drugs
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
49 Immunizing Drugs
Immunity and Immunization
Immunizing Drugs
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
Part 9 Drugs Affecting the Gastrointestinal System and Nutrition
50 Acid-Controlling Drugs
Overview
Acid-Related Pathophysiology
Antacids
Drug Profiles
H2 Receptor Antagonists
Drug Profiles
Proton Pump Inhibitors
Drug Profiles
Miscellaneous Acid-Controlling Drugs
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
51 Bowel Disorder Drugs
Overview
Antidiarrheals
Drug Profiles
Laxatives
Drug Profiles
Drugs for Irritable Bowel Syndrome
Nursing Process
Critical Thinking Exercises
Review Questions
References
52 Antiemetic and Antinausea Drugs
Nausea and Vomiting
Antiemetic Drugs
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
53 Vitamins and Minerals
Overview
Pharmacology Overview
Fat-Soluble Vitamins
Drug Profile
Drug Profiles
Drug Profile
Drug Profile
Water-Soluble Vitamins
Drug Profile
Drug Profile
Drug Profile
Drug Profile
Drug Profile
Drug Profile
Minerals
Drug Profile
Drug Profile
Drug Profile
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
54 Anemia Drugs
Erythropoiesis
Types of Anemia
Erythropoiesis-Stimulating Drugs
Drug Profiles
Iron
Drug Profiles
Folic Acid
Drug Profile
Other Anemia Drugs
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
55 Nutritional Supplements
Overview
Enteral Nutrition
Drug Profiles
Parenteral Nutrition
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
Part 10 Dermatologic, Ophthalmic, and Otic Drugs
56 Dermatologic Drugs
Overview
Pharmacology Overview
Antimicrobials
Drug Profiles
Drug Profiles
Drug Profiles
Anesthetic, Antipruritic, and Antipsoriatic Drugs
Drug Profiles
Miscellaneous Dermatologic Drugs
Drug Profiles
Wound Care Drugs
Skin Preparation Drugs
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
57 Ophthalmic Drugs
Overview
Pharmacology Overview
Antiglaucoma Drugs
Drug Profiles
Drug Profiles
Drug Profiles
Drug Profile
Drug Profiles
Drug Profile
Antimicrobial Drugs
Drug Profiles
Antiinflammatory Drugs
Drug Profiles
Topical Anesthetics
Drug Profile
Diagnostic Drugs
Drug Profiles
Miscellaneous Drugs
Drug Profiles
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
58 Otic Drugs
Overview
Treatment of Ear Disorders
Antibacterial and Antifungal Otic Drugs
Drug Profiles
Earwax Emulsifiers
Drug Profile
Nursing Process
Key Points
Critical Thinking Exercises
Review Questions
References
Appendix Pharmaceutical Abbreviations
Answers to Review Questions
Index
Special Features
