Pharmacological studies on dithranol-induced irritative dermatitis in mice

✍ Scribed by L. Kemény; M. Csató; A. Dobozy

• Book ID: 104763997
• Publisher: Springer-Verlag
• Year: 1989
• Tongue: English
• Weight: 335 KB
• Volume: 281
• Category: Article
• ISSN: 0340-3696
• DOI: 10.1007/bf00412983

✦ Synopsis

The effects of different pharmacological substances on dithranoi-induced irritative dermatitis were studied in mice. Pretreatment of the animals with a specific platelet activating factor (PAF) antagonist, BN 52021, significantly reduced the ear swelling in a dosedependent manner. The cyclooxygenase inhibitor indomethacin, the antihistamine clemastine, and the antioxidant superoxide dismutase also proved to be effective in the reduction of the dermatitis.

The results provide evidence of the coinvolvement of PAF, prostaglandins, histamine, and reactive oxygen radicals in dithranol-induced irritative dermatitis in mice.