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Pharmacological separation between peripheral and central functions of cyclooxygenase-2 with CIAA, a novel cyclooxygenase-2 inhibitor

✍ Scribed by Takako Okumura; Yoko Murata; Masanori Hizue; Tomomi Matsuura; Rie Naganeo; Yoshihito Kanai; Akio Murase; Ayano Sakakibara; Isami Fujita; Kazunari Nakao

Book ID: 113586149
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 195 KB
Volume: 539
Category: Article
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2006.04.007

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## Abstract The potent chemopreventive activity of cyclooxygenase‐2 (COX‐2) inhibitors has been demonstrated in a number of preclinical studies, but their potency in antitumor activity is still in dispute. In this report, we demonstrate the potent antitumor activity of a novel COX‐2 inhibitor, CS‐7