Preclinical pharmacology profile of CS-706, a novel cyclooxygenase-2 selective inhibitor, with potent antinociceptive and anti-inflammatory effects

CS-706, a novel cyclooxygenase-2 selecti

CS-706, a novel cyclooxygenase-2 selective inhibitor, prolonged the survival of tumor-bearing mice when treated alone or in combination with anti-tumor chemotherapeutic agents

✍ Michiyo Senzaki; Saori Ishida; Ayumi Yada; Masaharu Hanai; Kosaku Fujiwara; Shin 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 176 KB

## Abstract The potent chemopreventive activity of cyclooxygenase‐2 (COX‐2) inhibitors has been demonstrated in a number of preclinical studies, but their potency in antitumor activity is still in dispute. In this report, we demonstrate the potent antitumor activity of a novel COX‐2 inhibitor, CS‐7