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Pharmacological selectivity of the in vivo binding of [11C]NNC 112 and [11C]SCH 23390 in the cortex: A PET study in baboons

✍ Scribed by J. Ekelund; R. Narendran; O. Guillain; J. Castrillon; D. Hwang; M. Slifstein; A. Abi-Dargham; Marc Laruelle


Book ID
118490020
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
50 KB
Volume
31
Category
Article
ISSN
1053-8119

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The dopamine D-1 receptor antagonist, SCH 23390 ((R)-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3- benzazepin-7-ol), was labelled by alkylation of the desmethyl compound SCH 24518 ((R)-(+)-8-chloro-2,3,4,5-tetrahydro-5-phenyl-1H-3-benzazepin-7- ol) with [11C]methyl iodide. A multivariate o