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Pharmacological profile of a novel class of muscarinic acetylcholine receptor agonists

✍ Scribed by Per Sauerberg; Bjarne Fjalland; Jens-Jørgen Larsen; Thomas Bach-Lauritsen; Erik Falch; Povl Krogsgaard-Larsen

Book ID
115879880
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
486 KB
Volume
130
Category
Article
ISSN
0014-2999

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✍ Daniel V. Widzowski; Paul Bialobok; Kris E. Kucera; Roberta Mihut; Shawn Sitar; 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 178 KB

The purpose of these studies was to determine the levels of intrinsic activity in vitro at muscarinic receptor pharmacological subtypes (M 1 , M 2 , and M 3 ) that would optimize cognitive activity while minimizing acute adverse cholinergic effects in vivo. These levels of intrinsic efficacy at M 1