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Pharmacological profile of a new orally active growth hormone secretagogue, SM-130686

โœ Scribed by Nagamine, J

Book ID
118026309
Publisher
Bioscientifica
Year
2001
Tongue
English
Weight
151 KB
Volume
171
Category
Article
ISSN
0022-0795

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Synthesis of the orally active spiroindo
Synthesis of the orally active spiroindoline-based growth hormone secretagogue, MK-677
โœ Peter E. Maligres; Ioannis Houpis; Kai Rossen; Audrey Molina; Jess Sager; Veena ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 706 KB

The preparation of the Merck Growth Hormone Secretagogue; MK-677 is described. A Fischer indole/reduction based strategy provides the novel spiroindoline nucleus of this potent compound. This optimized sequence necessitates the isolation of only one intermediate 10 and provides MK-677 in 48% overall