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Pharmacological, neurochemical, and behavioral profile of JB-788, a new 5-HT1A agonist

✍ Scribed by M. Picard; S. Morisset; J.F. Cloix; J.C. Bizot; M. Guerin; V. Beneteau; G. Guillaumet; T.K. Hevor


Book ID
116789250
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
1003 KB
Volume
169
Category
Article
ISSN
0306-4522

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LY301317 ((4r)-(-)-4-(dipropylamino)-6-(5-oxazolinyl)-1, 3,4,5-tetrahydrobenz[c,d]indole) has high affinity for the 5-HT 1A receptor and weak affinity for the 5-HT 1D and histamine-H 1 receptors. No significant affinity was found for the other amine receptors studied. In rats, LY301317 produced pote