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P-19-21 - Pharmacological profile of OPC-14523 (1): A novel sigma and 5-HT1A receptor agonist

โœ Scribed by K. Tottori; T. Kikuchi; Y. Uwahodo; M. Nakai; T. Miwa; Y. Oshiro; S. Morita


Book ID
119177889
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
153 KB
Volume
6
Category
Article
ISSN
0924-977X

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LY301317 ((4r)-(-)-4-(dipropylamino)-6-(5-oxazolinyl)-1, 3,4,5-tetrahydrobenz[c,d]indole) has high affinity for the 5-HT 1A receptor and weak affinity for the 5-HT 1D and histamine-H 1 receptors. No significant affinity was found for the other amine receptors studied. In rats, LY301317 produced pote