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Pharmacological modulation of geranylgeranyltransferase and farnesyltransferase attenuates opioid withdrawal in vivo and in vitro

✍ Scribed by Rehni, Ashish K.; Singh, Thakur Gurjeet


Book ID
122377461
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
720 KB
Volume
71
Category
Article
ISSN
0028-3908

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Farnesyltransferase catalyzes the posttranslational modification of numerous proteins involved in intracellular signal transduction by transferring the farnesyl residue of farnesyl pyrophosphate to the thiol of a cysteine side chain of the protein substrate. The cysteine residue belongs to a charact