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Pharmacological modulation of beta-endorphin in rat peritoneal macrophages

✍ Scribed by Paola Sacerdote And; Alberto E. Panerai

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
244 KB
Volume
3
Category
Article
ISSN
0887-8013

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✦ Synopsis

The neuropeptide beta-endorphin is present in cells of the immune system, i.e., lymphocytes and monocytes, and its expression can be induced by immunological stimuli.

In the present study, we showed that the increase of the serotoninergic availability induces an increase of beta-endorphin concentrations in rat peritoneal macrophages that is blunted by the administration of serotonin receptor antagonists. A significant increase of beta-endorphin concentrations is also evident after blocking the dopaminegic receptors, whereas a dopaminergic agonist decreases the concentrations of the peptide. Our data are consistent with a similar modulation of beta-endorphin concentrations in central nervous system and in immune cells, e.g., rat peritoneal macrophages.

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