Pharmacological Actions of Naringin on Alpha, Beta-adrenoceptors and Uptake of Noradrenaline in Rat Isolated Vas Deferens
✍ Scribed by M. D. Herrera; E. Marhuenda
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 256 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
normal k e b s sohtion, naringin (1 X lo-' M-2 X M) enhanced noradrenaline-induced contractions in rat isolated vas deferens increasing this potentiation in a concentration dependent manner. This enhancing effect continued in the presence of yohimbine (lo-' M) or propranolol M ) . Naringin did not modify significantly the dopamine dose-response curves. In a medium containing lo-* M prazdn, naringin decreased noradrenaline dose-response curves underneath the control curve at all the doses tested. Naringin did not modify significantly the NA dose-response curve in a medium containing cocaine (lo-' M) or oestradiol (lo-' M). The potentiation produced by naringin on the NA-induced contractions in rat vas deferens may be due to alpha-1 receptor activation, together with an interference of naringin in catecholamine uptake process.