✦ LIBER ✦

Pharmacological investigation of Ocimum gratissimum in rodents

✍ Scribed by P. I. Aziba; D. Bass; Y. Elegbe

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 51 KB
Volume: 13
Category: Article
ISSN: 0951-418X
DOI: 10.1002/(sici)1099-1573(199908/09)13:5<427::aid-ptr467>3.0.co;2-t

No coin nor oath required. For personal study only.

✦ Synopsis

The pharmacological activities were screened of aqueous extracts of Ocimum gratissimum in isolated rabbit jejunum (IRJ); rat stomach strip (RSS); and also its analgesic properties in mice.

The extract caused a dose dependent inhibition of the rabbit jejunum spontaneous pendular movement. The blocking effect on acetylcholine induced contraction was non-competitive in the rat stomach strip since maximum contractions were suppressed and no parallel shift was observed in the curve. The result of the analgesic study showed that the extract evoked a prolongation of reaction time of 85% ( p `0.05) over 20 min observation time with no overt signs of toxicity.

These results suggest the presence of analgesic and spasmolytic activities.

📜 SIMILAR VOLUMES

Pharmacological evaluation of Hoslundia

Pharmacological evaluation of Hoslundia opposita extract in rodents

✍ O. A. Olajide; O. O. Oladiran; S. O. Awe; J. M. Makinde 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 69 KB

A chloroform extract of the dried root of Hoslundia opposita was studied for its analgesic, antipyretic and antiinflammatory activities. A significant protection against the acetic acid-induced writhing response in mice, and a marked lowering of the body temperature of hyperthermic mice was observed

Chemical investigation of Ocimum species

Chemical investigation of Ocimum species growing in Togo

✍ Komla Sanda; Koffi Koba; Phintè Nambo; Antoine Gaset 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 152 KB

The steam-distilled leaf and ¯ower oils of Ocimum basilicum L., Ocimum canum Sims and Ocimum gratissimum L., collected from 14 dierent locations in Togo, have been studied. Capillary gas±liquid chromatography and capillary gas-chromatography coupled with mass spectrometry were used to determine the

The application of atmospheric pressure

The application of atmospheric pressure chemical ionisation liquid chromatography–mass spectrometry in the chemotaxonomic study of flavonoids: characterisation of flavonoids from Ocimum gratissimum var. gratissimum

✍ Renée J. Grayer; Geoffrey C. Kite; Mamdouh Abou-Zaid; Louise J. Archer 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 124 KB 👁 2 views

Essential oil composition of Ocimum basi

Essential oil composition of Ocimum basilicum L., O. gratissimum L. and O. suave L. in the Republic of Guinea

✍ Sékou Moussa Kéita; Charles Vincent; Jean-Pierre Schmit; André Bélanger 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 62 KB 👁 3 views

Specimens of Ocimum basilicum L[\ O[ `rattisimum and O[ sauve L[ were collected at Coyah\ Kindia and Faranah in the Republic of Guinea "voucher specimens were deposited in the herbarium of the Environmental Studies and Research Center "ERSC#\ University of Conakry!Guinea#[ Steam distillation of the

In vivo pharmacology and antidiarrheal e

In vivo pharmacology and antidiarrheal efficacy of a thiazolidinone CFTR inhibitor in rodents

✍ N.D. Sonawane; Chatchai Muanprasat; Ray Nagatani Jr.; Yuanlin Song; A.S. Verkman 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 218 KB

ChemInform Abstract: Synthesis and Preli

ChemInform Abstract: Synthesis and Preliminary Pharmacological Investigations of 1-(1,2-Dihydro-2-acenaphthylenyl)piperazine Derivatives as Potential Atypical Antipsychotic Agents in Mice.

✍ P. Srinivas; A. R. Subramanian; P. Brust; S. A. V. Raghavan; J. B. Rangisetty; C 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB