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Pharmacological characterization of novel iminoheterocyclic BACE1 inhibitors for the treatment of Alzheimer's disease

✍ Scribed by Kennedy, Matthew E.; Chen, Xia; Kuvelkar, Reshma; Cumming, Jared; Iserloh, Ulrich; McKittrick, Brian; Pan, Janping; Smith, Elizabeth; Sun, Zhong-Yue; Stamford, Andrew; Zhu, Zhaoning; Beyer, Brian; Strickland, Corey; Voigt, Johannes; Wang, Yu-Sen; Wyss, Daniel; Parker, Eric M.

Book ID
122906901
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
47 KB
Volume
6
Category
Article
ISSN
1552-5260

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## Abstract β‐Amyloid cleaving enzyme‐1 (BACE1) has become a significant target for the therapy of Alzheimer's disease. After the discovery of the first non‐peptidomimetic β‐secretase inhibitors by Takeda Chemicals in 2001, several research teams focused on SAR development of these agents. The non‐