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Bace Inhibitors for the Treatment of Alzheimer's Disease

✍ Scribed by Johanna Fälting; Jan Neelissen; Fredrik Jeppson; Anki Radesäter; Susanna Eketjäll; Peter Söderman; Britt-Marie Swahn; Biljana Georgievska

Book ID
118465714
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
64 KB
Volume
5
Category
Article
ISSN
1552-5260

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## Abstract β‐Amyloid cleaving enzyme‐1 (BACE1) has become a significant target for the therapy of Alzheimer's disease. After the discovery of the first non‐peptidomimetic β‐secretase inhibitors by Takeda Chemicals in 2001, several research teams focused on SAR development of these agents. The non‐