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Pharmacological Characterization of 6-Bromo-3′-nitroflavone, a Synthetic Flavonoid with High Affinity for the Benzodiazepine Receptors

✍ Scribed by C. Wolfman; H. Viola; M. Marder; P. Ardenghi; C. Wasowski; N. Schröder; I. Izquierdo; E. Rúveda; A. Paladini; J.H. Medina


Book ID
114104004
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
834 KB
Volume
61
Category
Article
ISSN
0091-3057

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6-Bromo-3′-nitroflavone, a new high affi
✍ Haydee Viola; Mariel Marder; Claudia Wolfman; Cristina Wasowski; Jorge H. Medina 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 233 KB

The synthesis and biochemical characterization of 6-bromo-3'-nitroflavone (1) is presented Compound 1 has higher affinity for cerebellar and cerebral cortical than for striatal, hippocampal, or spinal cord benzodiazepine receptors (BDZ-Rs). In the cerebral cortex it recognizes two populations of bin