6-Bromo-3′-nitroflavone, a new high affinity benzodiazepine receptor agonist recognizes two populations of cerebral cortical binding sites

✍ Scribed by Haydee Viola; Mariel Marder; Claudia Wolfman; Cristina Wasowski; Jorge H. Medina; Alejandro C. Paladini

• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 233 KB
• Volume: 7
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/s0960-894x(97)00020-6

✦ Synopsis

The synthesis and biochemical characterization of 6-bromo-3'-nitroflavone (1) is presented Compound 1 has higher affinity for cerebellar and cerebral cortical than for striatal, hippocampal, or spinal cord benzodiazepine receptors (BDZ-Rs). In the cerebral cortex it recognizes two populations of binding sites (K,s 1.2 nM and 15.5 riM, respectively), and at doses of 0.01 to 0.3 mg/kg, ip produces anxiolytic effects in mice