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Pharmacological blood-brain barrier modification for selective drug delivery

✍ Scribed by Timothy F. Cloughesy; Keith L. Black


Book ID
105053919
Publisher
Springer US
Year
1995
Tongue
English
Weight
668 KB
Volume
26
Category
Article
ISSN
0167-594X

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## Abstract Glial‐derived neurotrophic factor (GDNF) is a neurotrophin that could be developed as a neurotherapeutic for Parkinson's disease, stroke, and motor neuron disease. However, GDNF does not cross the blood–brain barrier (BBB). Human GDNF was re‐engineered by fusion of the mature GDNF prote